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“EXPANDING THE SCOPE OF STROKE TREATMENT”

New Perspectives on Clinical Trial Enrollment,

Patient Selection and Evolving Therapies 

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 DAY 1 TUESDAY MORNING, MARCH 21 

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* All Meals are served in Salons 1-3 Adjacent to the Ballroom

* Ballroom – Main Floor of Hotel – Location of all General Sessions - (V) indicates Virtual

* Presentations are 10 minutes each. Session 3, Topic 4 is 15 minutes allowing for two speakers

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7:00 – 8:00   Full Breakfast Provided  -- Salons 1-3

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8:00 – 8:15     WELCOME AND OPENING REMARKS  -- Ballroom

STAIR XII Chair - Greg Albers and Vice Chair - Marc Fisher​

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8:15 – 10:15    SESSION 1    ACUTE STROKE TRIALS: NEW DATA, NEW LANDSCAPE, NEW APROACHES (Part 1)         

Session Chairs:  Walter Koroshetz and Argye Hillis

• Trials of cytoprotective agents prior to reperfusion: – David Liebeskind

• Treatments for reperfusion injury– Midori Yenari

• Neuromodulatory devices for acute stroke (transcranial direct current stimulation, focused ultrasound stimulation, sphenopalatine ganglion stimulation, and trigeminal nerve stimulation) – Mersedeh Bahr

• Novel Device Technologies in Mechanical Thrombectomy for Stroke – Raul Nogueira​

ROUNDTABLE PANEL DISCUSSION: Nirav Bhatt, Yunyun Xiong (V), Destiny Hooper and Michael Tymianski

 

10:15 – 10:30        Refreshment Break  -- Foyer Outside of Ballroom

 

10:30 – 12:00   SESSION 2    ACUTE STROKE TRIALS: NEW DATA, NEW LANDSCAPE, NEW APROACHES (Part 2)

Session Chairs:  Sean Savitz and David Fiorella

• Factors leading to poor outcomes in successfully reperfused patients?  –  Michael Hill

• How to improve outcomes following endovascular reperfusion (clinical management) – Eva Mistry

• How to improve outcomes following endovascular reperfusion (new therapeutics) – Kevin Sheth

• Current status of EVT indication expansion trials – Amrou Sarraj​

ROUNDTABLE PANEL DISCUSSION: Thanh N. Nguyen, Fana Alemseged, Dileep Yavagal, Natan Bornstein and Rano Chatterjee

 

12:00 – 1:00    LUNCH PROVIDED  -- Salons 1-3

 

DAY 1  TUESDAY AFTERNOON  -- Ballroom 

 

1:00 – 2:15      SESSION 3   HOW TO ENHANCE ENROLLMENT & PATIENT SELETION IN CLINICAL TRIALS

Session Chairs:  Wade Smith and Pat Lyden

• Decentralized and virtually-enabled clinical trials: legal, regulatory and workflow implications for design and execution – Lee Schwamm

• Collateral assessment, AI-based Imaging Apps – Jeremy Heit

• Stroke detection wearables / devices to facilitate stroke detection in the ambulance – Jeff Saver (V)

• Digital Health / Models of Pre-hospital Triage – Gisele Silva / Kori Zachrison​

ROUNDTABLE PANEL DISCUSSION:  Christine Holmstedt, Jordan Elm and J Mocco

 

2:15 – 3:30      SESSION 4    INTRAVENOUS THROMBOLYIS / ICH THERAPY

Session Chairs: Andrei Alexandrov and Opeolu Adeoye

• Update on Thrombolytics: Is TNK the preferred agent? – Shelagh Coutts

• When is an IV lytic needed prior to thrombectomy & should IA lytics be given post-EVT? – Bruce Campbell

• Challenges of designing trials for novel clot-dissolving agents in the current clinical landscape – Pooja Katri

• New approaches to treatment of ICH – Magdy Selim​

ROUNDTABLE PANEL DISCUSSION: Edward Jauch, Yasmin Aziz, Barbara Purdon and Josh Bell

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3:30 – 3:45       Refreshment Break  -- Foyer Outside of Ballroom

 

3:45 – 5:15      SESSION 5   REGULATORY PERSPECTIVES ON KEY CLINICAL TRIAL ISSUES  

Session Chairs: Scott Kasner and  Greg Albers  

• NINDS Update – Clinton Wright 

• FDA Panel (CDER & CDRH) Answers to Stroke Community Questions from pre-conference participant surveys and audience questions; Heather Fitter,  FDA/CDER; Xiaolin Zheng, John Marler (V)  FDA/CDRH

ROUNDTABLE PANEL DISCUSSION:   FDA, NINDS, Michael Marks and Mike Wald

 

6:30 – 7:30      SPONSORED RECEPTION -- Studio B – Main Floor of Hotel

 

7:30 – 9:00      DINNER BANQUET   -- Ballroom 

   FOLLOWED BY SPECIAL PRESENTATION

       “The History and Future of Acute Stroke Treatment”     

Special Guest Speaker: Dr. James Grotta

                         

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DAY 2  WEDNESDAY MORNING, MARCH 22 

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7:00 – 8:00     FULL BREAKFAST PROVIDED  -- Salons 1-3

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 * All Participants - Please Report Directly to Your Assigned Workshop at 8:00 AM 

 * All Workshops held in Studios B, D and F on Main Floor of Hotel

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8:00 – 10:30   WORKSHOPS TO DEVELOP RECOMMENDATIONS 

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 * Participants divide into three groups according to their topic choice

 * Each group will develop recommendations on their selected topic

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WORKSHOP 1:   MOST PROMISING APPROACHES TO IMPROVE STROKE OUTCOMES

Studio - B               Facilitators – Chair: Larry Wechsler, Co-chair: Shadi Yaghi,

                                Discussion Organizer: Johannes Bolt

 

WORKSHOP 2:   OPTIMIZING IMAGING FOR PATIENT SELECTION

Studio - D               Facilitators – Chair: Maarten Lansberg, Co-chair: Edgar Samaniego

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WORKSHOP 3:   HOW TO ENHANCE ENROLLMENT IN ACUTE STROKE TRIALS

Studio - F                Facilitators – Chair: Joe Broderick, Co-chair: Hooman Kamel

 

10:30 – 10:45         Refreshment Break  

 

10:45 – 12:00       WORKSHOP CHAIRS PRESENT RECOMMENDATIONS TO FULL ASSEMBLY

Reconvene          Drafting of consensus statements is initiated – Chaired by Greg Albers and Marc Fisher

in Ballroom              

 

12:00 – 12:15      CLOSING COMMENTS AND ADJOURNMENT

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STAIR MISSION STATEMENT

The STAIR Consensus Conferences, via a collaboration of medical academia, the healthcare industry and government agencies, are intended to advance and accelerate stroke research to ultimately result in improved stroke acute treatment, care and prevention. To achieve this goal, STAIR will:

•   Develop new approaches to overcome barriers impeding stroke drug and device development

•   Identify, clarify and communicate the implications of new research to the stroke field

•   Publish STAIR Workshop recommendations developed by participants which address these concerns

•   Promote adoption of STAIR solutions by research, industry, clinical and government communities